Remotiv® (Ze 117) has been shown to assist in the relief of nervous tension, stress and mild anxiety.1 Remotiv contains a specific extract of St John’s wort (Hypericum perforatum) that has been evaluated in a number of clinical trials. St John's wort has been used since the middle ages to help manage anxiety and stress. It was the ancient Greek herbalists, such as Hippocrates, who originally documented the medicinal uses of St John’s wort.